Studies on changes of ligandin and glutathiqne S-transferase durihg 3'-methyl-4-dimethylaminoazobenzene hepatocarcinogenesis
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منابع مشابه
The Crystallographic, Spectroscopic and Theoretical Studies on (E)-2-[((4-fluorophenyl)imino)methyl]-4-nitrophenol and (E)-2-[((3-fluorophenyl)imino)methyl]-4-nitrophenol Compounds
In this study, two new salicylideneaniline derivative compounds which are an isomer of each other have been synthesized and characterized by X-Ray Diffraction (XRD) technique, IR spectroscopy, and theoretical method. While (E)-4-(dihydroxyamino)-2-(((4-fluorophenyl)imino) methyl)phenol (1), crystalizes triclinic P-1 space group, (E)-4-(dihydroxyamino)-2-(((3-fluorophenyl)im...
متن کاملThe effect of feeding 3'-methyl-4-dimethylaminoazobenzene on tryptophan metabolism of rats.
Liver tryptophan pyrrolase and kynureninase activity decreased when rats were fed the hepatic carcinogen 3'-methyl-4-dimethylaminoazobenzene, whereas li ver kynurenine transaminase activity did not differ significantly from that of the controls. Liver tumors induced by this aminoazo dye had very low kynurenine transaminase activity and no detectable tryptophan pyrrolase or kynureninase activity...
متن کاملFine structural changes in hepatocytes after simultaneous treatment with single doses of 3'-methyl-4-dimethylaminoazobenzene and cycloheximide.
Male rats were given single doses p.o. of 3'-methyl-4-dimethylaminoazobenzne (3'-MeDAB), either alone or at the same time as single s.c. injections of cycloheximide. They were killed either 24 or 48 hr after treatment or at intervals up to 21 months, and their hepatic tissues were examined by electron density, combined treatment with both chemicals failed to produce this acute toxic effect. How...
متن کاملDistribution and turnover of cholesterol in rats fed 3'-methyl-4-dimethylaminoazobenzene.
Lit t le compara t ive work has been done on the effect of l iver damage and neoplasia, induced by p-d imethylaminoazobenzene derivat ives, on the cholesterol metabol i sm and tu rnover in rats. D a t a collected by Greenste in (9) demons t ra t ed t h a t ra t h e p a t o m a conta ined significantly more cholesterol t h a n did normal liver. Baker and Greenberg (1) showed t h a t the in vivo ...
متن کاملChanges in molecular forms of rat hepatic glutathione S-transferase during chemical hepatocarcinogenesis.
Changes in molecular forms of hepatic cytosolic glutathione S-transferases (GST) during rat chemical hepatocarcinogenesis were investigated. GST activities toward 1-chloro-2,4-dinitrobenzene and 1,2-dichloro-4-nitrobenzene increased with the increased area of gamma-glutamyltranspeptidase-positive foci and hyperplastic nodules induced by diethylnitrosamine followed by 2-acetylaminofluorene plus ...
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ژورنال
عنوان ژورنال: Kanzo
سال: 1980
ISSN: 0451-4203,1881-3593
DOI: 10.2957/kanzo.21.1532